P7262
Plumbagin from Plumbago indica
Sinonimo/i:
5-Hydroxy-2-methyl-1,4-naphthoquinone
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About This Item
Formula empirica (notazione di Hill):
C11H8O3
Numero CAS:
Peso molecolare:
188.18
Numero CE:
Numero MDL:
Codice UNSPSC:
12352205
ID PubChem:
NACRES:
NA.79
Prodotti consigliati
Origine biologica
Plumbago indica
Livello qualitativo
Stato
powder
Colore
faint orange to dark orange
Punto di fusione
76-78 °C (lit.)
Temperatura di conservazione
−20°C
Stringa SMILE
CC1=CC(C2=C(C1=O)C=CC=C2O)=O
InChI
1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
VCMMXZQDRFWYSE-UHFFFAOYSA-N
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Descrizione generale
Plumbagin is a bioactive naphthoquinone present majorly in Plumbago indica L. It is a quinoid and is also derived from the roots of Plumbago zeylanica roots.
Applicazioni
Plumbagin from Plumbago indica has been used:
- as a reactive oxygen species agent (ROS) to induce cytotoxicity in mouse embryonic fibroblasts
- as an oxidative stress inducer to generate superoxide anion in Saccharomyces cerevisiae
- as a reference standard in thin layer chromatography and in spectrophotometric analysis for quantification of plumbagin in Plumbago auriculate samples
Azioni biochim/fisiol
Exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.
Plumbagin exhibits various pharmacological activities including antimicrobial, anticancer, anti-atherosclerotic, antidiabetic, anti-inflammatory, hypolipidemic, and neuroprotective activities. It inhibits the signal transducer and activator of transcription 3 (STAT3) signaling and halts the proliferation of esophageal squamous cell carcinoma (ESCC). Plumbagin elicits protective antioxidative functionality in 4-nitroquinoline-N-oxide (NQNO) induced stress in lymphoma. Plumbagin in a nanoemulsion formulation has antiproliferative effect towards prostate cancer.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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