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Documenti fondamentali

SML1489

Sigma-Aldrich

FICZ

≥95% (HPLC), lyophilized powder, AhR agonist

Sinonimo/i:

5,11-Dihydro-indolo[3,2-b]carbazole-6-carboxaldehyde, 6-Formylindolo[3,2-b]carbazole

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About This Item

Formula empirica (notazione di Hill):
C19H12N2O
Numero CAS:
172922-91-7
Peso molecolare:
284.31
Codice UNSPSC:
12352200
NACRES:
NA.77

Nome del prodotto

FICZ, ≥95% (HPLC)

Livello qualitativo

100

Saggio

≥95% (HPLC)

Stato

lyophilized powder

Colore

yellow

Solubilità

DMSO: 0.5 mg/mL, clear (warmed)

Temperatura di conservazione

−20°C

Stringa SMILE

[nH]1c2c(c5c1cccc5)cc3[nH]c4c(c3c2C=O)cccc4

InChI

1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H
ZUDXFBWDXVNRKF-UHFFFAOYSA-N

Azioni biochim/fisiol

FICZ (6-formylindolo(3,2b)carbazole) being a photooxidation product of tryptophan, might serve as a chemical messenger of light.
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
046M4705V

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Benzo[a]pyrene ≥96% (HPLC)

Sigma-Aldrich

B1760

Benzo[a]pyrene

L-Kynurenine sulfate salt crystalline

Sigma-Aldrich

K3750

L-Kynurenine sulfate salt

Kynurenic acid ≥98%

Sigma-Aldrich

K3375

Kynurenic acid

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals.
Denison M S and Nagy S R
Annual Review of Pharmacology, 43(1), 309-334 (2003)
Sibei Tao et al.
Journal of cellular and molecular medicine, 25(2), 1035-1047 (2020-12-07)
Acute kidney injury (AKI) is a multifactorial disease of various aetiologies. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that responds to ligands to induce or repress gene expressions, thereby regulating a diverse spectrum of biological or pathophysiologic effects.
Yann Malaisé et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 104993-104993 (2020-09-11)
The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases. Regulatory restrictions have been established to prevent risks for
Hui Li et al.
FEBS letters, 593(9), 952-961 (2019-04-07)
Interleukin (IL)-17 plays a critical role in the pathogenesis of inflammation and autoimmune diseases. The aryl hydrocarbon receptor (AHR) is a transcription factor responsible for the elimination of xenobiotic chemicals. However, it remains unknown whether AHR is involved in IL-17
Barbora Vyhlídalová et al.
International journal of molecular sciences, 21(7) (2020-04-15)
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed substantially, comprising
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