SML1278

Geldanamycin Ready Made Solution

1 mg/mL, from Streptomyces hygroscopicus

• Sinonimo/i: 2-Azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9,13-dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-, 9-carbamate (8CI)
• Formula empirica (notazione di Hill): C₂₉H₄₀N₂O₉
• Numero CAS: 30562-34-6
• Peso molecolare: 560.64
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Origine biologica: Streptomyces hygroscopicus
• Livello qualitativo: 200
• Stato: DMSO solution
• Condizioni di stoccaggio: protect from light
• Concentrazione: 1 mg/mL
• Spettro attività antibiotica: neoplastics
• Modalità d’azione: enzyme | inhibits
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: N1C2=CC(=O)C(=C(C[C@H](C[C@@H]([C@@H]([C@H](\C=C(\[C@@H]([C@H](\C=C/C=C(/C1=O)\C)OC)OC(=O)N)/C)C)O)OC)C)C2=O)OC
• InChI: 1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1; QTQAWLPCGQOSGP-KSRBKZBZSA-N

Descrizione

Descrizione generale

Chemical structure: benzenoid

Applicazioni

Geldanamycin Ready-Made Solution has been used as a heat shock protein 90 (Hsp90) inhibitor to pre-treat proteosome holo-enzyme during proteasome assay to study the role of proteasome on fibril fragmentation.

Azioni biochim/fisiol

Geldanamycin is a benzoquinone ansamycin and is a well known tyrosine kinase inhibitor. It possesses anticancer effects and shows therapeutic effects against osteosarcoma.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 188.6 °F
• Punto d’infiammabilità (°C): 87 °C