Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

SML0577

Sigma-Aldrich

Cucurbitacin E

≥95% (HPLC)

Sinonimo/i:

α-Elaterin, α-Elaterine

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C32H44O8
Numero CAS:
18444-66-1
Peso molecolare:
556.69
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥95% (HPLC)

Stato

powder

Attività ottica

[α]/D -60 to -75°, c = 0.7 (CDCl3)

Colore

white to beige

Solubilità

DMSO: 15 mg/mL, clear

Temperatura di conservazione

−20°C

InChI

1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1
NDYMQXYDSVBNLL-MUYMLXPFSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Applicazioni

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

Azioni biochim/fisiol

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
047M4706V
036M4703V
033M4707V

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 8

1 of 8

Jasplakinolide ≥97% (HPLC)

Sigma-Aldrich

J4580

Jasplakinolide

Myricetin ≥96.0%, crystalline

Sigma-Aldrich

M6760

Myricetin

Sennoside A analytical standard

Supelco

68909

Sennoside A

Calpeptin ≥98% (HPLC)

Sigma-Aldrich

C8999

Calpeptin

Pinocembrin analytical standard, ≥95.0% (HPLC), solid

Supelco

P5239

Pinocembrin

Latrunculin A from sea sponge, ≥85% (HPLC), waxy solid

Sigma-Aldrich

L5163

Latrunculin A

Esculin hydrate ≥98%

Sigma-Aldrich

E8250

Esculin hydrate

Angiotensina II umana ≥93% (HPLC), powder

Sigma-Aldrich

A9525

Angiotensina II umana

Pei-Lin Wu et al.
Chemical & pharmaceutical bulletin, 52(3), 345-349 (2004-03-03)
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray
Manali Dimri et al.
Development (Cambridge, England), 144(14), 2595-2605 (2017-07-20)
The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely established is not clear. We designed a new computer-based algorithm that quantitatively computes the structural differences of the
Yasuyuki Sadzuka et al.
International journal of pharmaceutics, 354(1-2), 63-69 (2007-12-07)
We screened various food components for their ability to inhibit doxorubicin (DOX) permeability in tumor cells in vitro with the aim of finding novel modulators. Capsaicin did not change DOX permeability in the tumor cells, although the capsaicin derivatives gingerol
Tehila Tannin-Spitz et al.
Biochemical and biophysical research communications, 364(1), 181-186 (2007-10-19)
The cucurbitacins are of great interest because of the wide range of biological activities they exhibit in plants and animals. We studied the antioxidant properties of cucurbitacin B + E glucosides (cucurbitacin glucoside combination, CGC) and their direct free-radical scavenging
Yanmin Dong et al.
Carcinogenesis, 31(12), 2097-2104 (2010-08-25)
Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound from folk traditional Chinese medicine plants, has been shown to inhibit cancer cell growth, inflammatory response and bilirubin-albumin binding. However, the effects of CuE on tumor angiogenesis and its potential molecular mechanism
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.