SML0481

Qc1

≥98% (HPLC)

• Sinonimo/i: 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
• Formula empirica (notazione di Hill): C₂₃H₁₆F₃N₃O₂S
• Numero CAS: 403718-45-6
• Peso molecolare: 455.45
• Numero MDL: MFCD02649259
• Codice UNSPSC: 12352200
• ID PubChem: 329825432
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 5 mg/mL (clear solution, warmed)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4
• InChI: 1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32); IFNVTSPDMUUAFY-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH).

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC₅₀ value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC₅₀ of 3 mM.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable