SML0006
CK-666
≥98% (HPLC), powder, Arp2/3 comple inhibitor
Sinonimo/i:
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666
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About This Item
Formula empirica (notazione di Hill):
C18H17FN2O
Numero CAS:
Peso molecolare:
296.34
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
CK-666, ≥98% (HPLC), powder
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to tan
Solubilità
DMSO: ≥25 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
UXRKUKRXVWJFER-UHFFFAOYSA-N
Categorie correlate
Applicazioni
CK-666 may be used to study Arp2/3-mediated structural changes in cells.
Azioni biochim/fisiol
CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
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