SML0006
CK-666
≥98% (HPLC), powder, Arp2/3 comple inhibitor
Sinonimo/i:
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK 666, CK-0944666
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About This Item
Formula empirica (notazione di Hill):
C18H17FN2O
Numero CAS:
Peso molecolare:
296.34
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
CK-666, ≥98% (HPLC), powder
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to tan
Solubilità
DMSO: ≥25 mg/mL
Temperatura di conservazione
2-8°C
Stringa SMILE
Cc1[nH]c2ccccc2c1CCNC(=O)c3ccccc3F
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
UXRKUKRXVWJFER-UHFFFAOYSA-N
Applicazioni
CK-666 may be used to study Arp2/3-mediated structural changes in cells.
Azioni biochim/fisiol
CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
CK-666 is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
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Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to Arp2/3 complex and inhibit nucleation, but their modes of action are unknown. Here, we use biochemical and structural
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Symmetry breaking is involved in many developmental processes that form bodies and organs. One of them is the epithelial rotation of developing tubular and acinar organs. However, how epithelial cells move, how they break symmetry to define their common direction
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