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Merck
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Key Documents

Altri documenti

SML0440

Sigma-Aldrich

Spautin-1

≥98% (HPLC)

Sinonimo/i:

6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43

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About This Item

Formula empirica (notazione di Hill):
C15H11F2N3
Numero CAS:
1262888-28-7
Peso molecolare:
271.26
Numero MDL:
MFCD16962292
Codice UNSPSC:
12352200
ID PubChem:
329824722
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: 15 mg/mL (clear solution)

Temperatura di conservazione

2-8°C

Stringa SMILE

FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2

InChI

1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
AWIVHRPYFSSVOG-UHFFFAOYSA-N

Applicazioni

Spautin-1 has been used as an autophagy inhibitor:
  • to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model
  • to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin
  • to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Azioni biochim/fisiol

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.
Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302 - H318

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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