SAB5200080
Monoclonal Anti-ITPR1 antibody produced in mouse
clone S24-18, 1 mg/mL, purified immunoglobulin
Sinonimo/i:
Anti-IP3 Receptor
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
S24-18, monoclonal
Forma fisica
buffered aqueous glycerol solution
PM
antigen predicted mol wt 300 kDa
Reattività contro le specie
human, mouse, rat
Concentrazione
1 mg/mL
tecniche
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Isotipo
IgG1
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
rat ... Itpr1(25262)
Categorie correlate
Descrizione generale
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) is highly expressed in the rat brain and is also seen in the heart. It possesses an inositol-triphosphate binding domain, a channel-forming region and a regulatory region. ITPR1 is composed of 2749 amino acids. The gene ID for the protein is 25262.
Specificità
Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R′s.
Immunogeno
Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1
Applicazioni
Monoclonal Anti-ITPR1 antibody produced in mouse has been used for Western blotting.
Azioni biochim/fisiol
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) takes part in Ca2+ signaling on binding to its ligand, inositol 1,4,5-trisphosphate.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.
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The Biochemical journal, 449(1), 39-49 (2012-09-27)
Binding of IP3 (inositol 1,4,5-trisphosphate) to the IP3-binding core (residues 224-604) of IP3Rs (IP3 receptors) initiates opening of these ubiquitous intracellular Ca2+ channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (residues 1-223). A
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