SAB4504104
Anti-phospho-PKD2 (pSer876) antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
Anti-HSPC187
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen 96 kDa
Reattività contro le specie
mouse, human, rat
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:60000
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
phosphorylation (pSer876)
Informazioni sul gene
human ... PRKD2(25865)
Descrizione generale
The protein kinase D2 (PRKD2) gene, mapped to human chromosome 4q21-23, codes for integral membrane protein polycystin-2. PRKD2 is a member of the serine/threonine protein kinase D (PRKD) family. It is characterized with two N-terminal cysteine-rich zinc finger domains involved in binding diacylglycerol (DAG) and phorbol esters, a central lipid/protein binding pleckstrin homology (PH) domain, and a C-terminal kinase domain. PRKD2 is mainly expressed in the endoplasmic reticulum (ER).
Immunogeno
The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser876.
Immunogen Range: 829-878
Immunogen Range: 829-878
Azioni biochim/fisiol
Protein kinase D2 (PRKD2) is a novel, essential mediator of tumor cell-endothelial cell communication and a promising therapeutic target to inhibit angiogenesis in gastrointestinal cancers. Mutation in the gene leads to autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 might function as a component of intracellular channel complexes. PRKD2 influences CD8+ T cell-dependent immune responses. PKD2 facilitates cell migration and it is associated with the progression and maintenance of various malignancies. Increased expression of PKD2 is observed in various types of cancers including colorectal cancer, glioblastoma multiforme (GBM). CRT0066101 acts as an inhibitor for all the three protein kinase D isoforms. Therefore, it can be used as a therapeutic drug for PRKD2 induced carcinogenesis.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Nisha Durand et al.
Journal of clinical medicine, 5(2) (2016-02-06)
The Protein Kinase D (PKD) isoforms PKD1, PKD2, and PKD3 are effectors of the novel Protein Kinase Cs (nPKCs) and diacylglycerol (DAG). PKDs impact diverse biological processes like protein transport, cell migration, proliferation, epithelial to mesenchymal transition (EMT) and apoptosis.
Y Cai et al.
The Journal of biological chemistry, 274(40), 28557-28565 (1999-09-25)
PKD2, the second gene for the autosomal dominant polycystic kidney disease (ADPKD), encodes a protein, polycystin-2, with predicted structural similarity to cation channel subunits. However, the function of polycystin-2 remains unknown. We used polyclonal antisera specific for the intracellular NH(2)
I Plastira et al.
Journal of neuroinflammation, 14(1), 253-253 (2017-12-21)
Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1-6) and are indispensible for brain development and function of the nervous system. However, under neuroinflammatory conditions or brain damage, LPA levels increase, thereby inducing signaling cascades
T Mochizuki et al.
Science (New York, N.Y.), 272(5266), 1339-1342 (1996-05-31)
A second gene for autosomal dominant polycystic kidney disease was identified by positional cloning. Nonsense mutations in this gene (PKD2) segregated with the disease in three PKD2 families. The predicted 968-amino acid sequence of the PKD2 gene product has six
Ninel Azoitei et al.
Gut, 59(10), 1316-1330 (2010-08-25)
Tumour angiogenesis is crucially dependent on the communication between the tumour and the associated endothelium. Protein kinase D (PKD) isoenzymes mediate vascular endothelial growth factor-A (VEGF-A) induced endothelial cell proliferation and migration and are also highly expressed in various tumours.
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