SAB4502989
Anti-TNF Receptor II, antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
CD120b, p75, p75 TNF receptor, p75TNFR
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen 48 kDa
Reattività contro le specie
human, rat, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:20000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TNFRSF1B(7133)
Descrizione generale
Tumor necrosis factor receptor 2 (TNFR2) gene with ten exons and nine introns, spanning approximately 43kbp is mapped to human chromosome 1p36.3-p36.2. TNFR2 is a member of TNF receptor superfamily, and it is expressed highly on cells of hematopoietic lineage. TNFR2, also known as CD120b or p75, TNF receptor is a 75-kDa type I transmembrane protein, characterized with cysteine-rich extracellular regions with three to six disulfide-linked domains required for ligand binding.
Immunogeno
The antiserum was produced against synthesized peptide derived from human TNF Receptor II.
Immunogen Range: 376-425
Immunogen Range: 376-425
Applicazioni
Anti-TNF Receptor 2 antibody has been used to study the effect of TNF signalling on CPF- and CPF+ CM (pesticides)-induced toxicity or apoptosis in SH-SY5Y cells.
Azioni biochim/fisiol
Tumor necrosis factor receptor 2 (TNFR2) plays a vital role in inducing signals for various cellular process, including proliferation of thymocytes and peripheral T cells, T cell secretion of granulocyte-macrophage colony-stimulating factor, inhibition of early hematopoiesis and the inactivation and clearance of TNF by the kidney. Mutation in the gene leads to hematopoietic cell malignancies, neuroblastoma, glioma and cervical and ovarian carcinoma. TRAF2 interacts with TNFR2 and activates NF-κB (NF-κB) pathway. TNFR2, which lack death domains modulates the effect of other death receptor TNFR1, which induces T cell death. TNFR2 plays an essential role in TNFα–induced leukocyte-endothelial interaction. TNFR2 is considered as a potential therapeutic alternative, as it has capacity to nullify the common side effects associated with drugs targeting TNF-α or p55.
Caratteristiche e vantaggi
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Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Yan Jiang et al.
Experimental and therapeutic medicine, 15(1), 1021-1028 (2018-02-13)
Tumor necrosis factor (TNF)-α has been reported to be important in glomerulonephritis, which is closely associated with podocyte dysfunction and apoptosis. However, the precise mechanisms by which TNF-α expression are regulated remain unclear. The purpose of the present study was
Unni M Chandrasekharan et al.
Blood, 109(5), 1938-1944 (2006-10-28)
Tumor necrosis factor-alpha (TNF-alpha) binds to 2 distinct cell-surface receptors: TNF-alpha receptor-I (TNFR-I: p55) and TNF-alpha receptor-II (TNFR-II: p75). TNF-alpha induces leukocyte adhesion molecules on endothelial cells (ECs), which mediate 3 defined steps of the inflammatory response; namely, leukocyte rolling
M Rothe et al.
Science (New York, N.Y.), 269(5229), 1424-1427 (1995-09-08)
TNF receptor-associated factor (TRAF) proteins are candidate signal transducers that associate with the cytoplasmic domains of members of the tumor necrosis factor (TNF) receptor superfamily. The role of TRAFs in the TNF-R2 and CD40 signal transduction pathways, which result in
S M Santee et al.
The Journal of biological chemistry, 271(35), 21151-21159 (1996-08-30)
Tumor necrosis factor receptor p75 (TNF-R p75) is a 75-kDa type I transmembrane protein expressed predominantly on cells of hematopoietic lineage. TNF-R p75 belongs to the TNF receptor superfamily characterized by cysteine-rich extracellular regions composed of three to six disulfide-linked
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley et al.
Cell, 104(4), 487-501 (2001-03-10)
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