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Key Documents

SAB4502676

Sigma-Aldrich

Anti-S6 Ribosomal Protein, C-Terminal antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

40S ribosomal protein S6, Phosphoprotein NP33, RPS6, RS6, ribosomal protein S6

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 28 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RPS6(6194)

Descrizione generale

Anti-S6 Ribosomal protein antibody detects endogenous levels of total S6 Ribosomal protein protein.
The RPS6 (ribosomal protein S6) gene is mapped to human chromosome 9p22.1.

Immunogeno

The antiserum was produced against synthesized peptide derived from human S6 Ribosomal Protein.

Immunogen Range: 191-240

Azioni biochim/fisiol

The RPS6 (ribosomal protein S6) protein is involved in the 40S subunit assembling. RpS6 might be involved in the regulation of cellular metabolism, the size of cells, their proliferation and survival. RpS6 might stimulate or inhibit translation of certain mRNA. Upregulation of the gene is observed in pulmonary sclerosing hemangioma, lymphangioleiomyomatosis-associated angiomyolipomas, dysplasia, oral cavity and esophageal squamous cell carcinoma.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer.
Chen B
Journal of Experimental & Clinical Cancer Research, 34:126, 1-16 (2015)
Janice Chithelen et al.
Frontiers in physiology, 13, 856143-856143 (2022-04-05)
The bioactive sphingolipids ceramide and sphingosine-1-phosphate (S1P) are involved in the regulation of cell homeostasis and activity ranging from apoptosis to proliferation. We recently described that the two compounds ceranib-2 (inhibiting acid ceramidase) and SKI-II [inhibiting the sphingosine kinases 1
Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.
Presneau N
British Journal of Cancer, 100(9), 1406-1414 (2009)
Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent.
Zhang D
Journal of Cellular Biochemistry, 117(7), 1649-1657 (2016)

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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