SAB4500487

Anti-PARP (Cleaved-Asp²¹⁴) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 24 kDa
• Reattività contro le specie: mouse, human
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:20000; western blot: 1:500-1:1000
• N° accesso NCBI: P09874
• N° accesso UniProt: P09874
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: proteolytically cleaved (Asp214)
• Informazioni sul gene: human ... PARP1(142)

Descrizione

Descrizione generale

Anti-PARP (Cleaved-Asp²¹⁴) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Asp²¹⁴) protein.

PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear protein that consists of three functional domains. It belongs to the PARP family. It is located on chromosome 1q42.

Immunogeno

The antiserum was produced against synthesized peptide derived from human PARP.

Immunogen Range: 165-214

Applicazioni

Anti-PARP (Cleaved-Asp214) antibody has been used in Western Blotting.

Azioni biochim/fisiol

PARP1 (poly (ADP-ribose) polymerase 1) participates in DNA repair. It serves as a facilitator of homologous recombination. It controls transcription by regulating chromatin structure, altering DNA methylation patterns, acting as a co-regulator of transcription factors and interacting with chromatin insulators. It also plays an important role in the protection of cardiovascular system.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable