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Key Documents

SAB4200840

Sigma-Aldrich

Anti-Pro LC3C antibody, Mouse monoclonal

clone BTY-1, purified from hybridoma cell culture Affinity isolated antibody

Sinonimo/i:

Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, MAP1 light chain 3-like protein 3, MAP1A/MAP1B LC3 C, MAP1A/MAP1B light chain 3 C, Microtubule-associated protein 1 light chain 3 gamma, Microtubule-associated proteins 1A/1B light chain 3C

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Tipo di anticorpo

primary antibodies

Clone

BTY-1, monoclonal

Forma fisica

liquid

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μL

Concentrazione

~1 mg/mL

tecniche

immunoblotting: 0.5-1 μg/mL using whole extracts of HEK-293T cells overexpressing human LC3C

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

Descrizione generale

Monoclonal Anti-Pro LC3C antibody (mouse IgG1 isotype) is derived from the BTY-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse. Human microtubule-associated proteins 1 light chain 3 (LC3C) is an ortholog of yeast Atg8. It is expressed in different human tissues. LC3C belongs to the subfamily of LC3 and the family of human Atg8. It is a structural protein of the autophagosomal membrane. LC3C gene is located on the human chromosome at 1q43.

Specificità

Monoclonal Anti-Pro LC3C antibody specifically recognizes epitope at the C-terminal pro-peptide domain of human LC3C-I and/or LC3C-II and dose not cross react with human LC3A or LC3B.

Immunogeno

Synthetic peptide corresponding to the C-terminal region of human LC3C, conjugated to KLH

Applicazioni

Anti-Pro LC3C antibody, mouse monoclonal may be used in immunoblotting and immunofluorescence.

Azioni biochim/fisiol

Human microtubule-associated proteins 1 light chain 3 (LC3C) protein is considered as an autophagy marker. It enhances the trafficking of hepatocyte growth factor (Met) receptor tyrosine kinase (RTK) to an autophagic compartment. LC3C protein also plays a role in antibacterial autophagy.

Stato fisico

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Stoccaggio e stabilità

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Esclusione di responsabilità

Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Autophagosome proteins LC3A, LC3B and LC3C have distinct subcellular distribution kinetics and expression in cancer cell lines
Koukourakis M I, et al.
PLoS ONE, 10(9), e0137675-e0137675 (2015)
Natalia von Muhlinen et al.
Molecular cell, 48(3), 329-342 (2012-10-02)
Autophagy protects cellular homeostasis by capturing cytosolic components and invading pathogens for lysosomal degradation. Autophagy receptors target cargo to autophagy by binding ATG8 on autophagosomal membranes. The expansion of the ATG8 family in higher eukaryotes suggests that specific interactions with

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