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SAB4200703

Sigma-Aldrich

Anti-Neurotensin/NTS antibody, Mouse monoclonal

clone NTS-11, purified from hybridoma cell culture

Sinonimo/i:

Anti- neurotensin, Anti-NMN125, Anti-NN, Anti-NT, Anti-NT/N

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.44

Origine biologica

mouse

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

NTS-11, monoclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

rat, human

Concentrazione

~1 mg/mL

tecniche

immunoblotting: 5-10 μg/mL using whole extract of SK-N-SH cells
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat brain sections

Isotipo

IgG1

N° accesso UniProt

P30990

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NTS(4922)
rat ... Nts(299757)

Descrizione generale

Anti-Neurotensin/NTS antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the NTS-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide. Neurotensin (also known as NTS or NT) is a 13 amino acid brain-gut peptide.

Immunogeno

Synthetic peptide from C-terminal region of human Neurotensin, conjugated to KLH

Applicazioni

Anti-Neurotensin/NTS antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

Azioni biochim/fisiol

Neurotensin (NTS) functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the gastrointestinal (GI) tract. Neurotensin is involved in a variety of physiological processes such as, stress and pain modulation, pathophysiology of drug addiction, schizophrenia, Parkinson disease, depression, locomotion and reward. In the brain, neurotensin modulates dopaminergic transmission in the nigrostriatal and mesocorticolimbic pathways as well as hormone secretion from the anterior pituitary.

Stato fisico

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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G S Katsanos et al.
International journal of immunopathology and pharmacology, 21(2), 255-259 (2008-06-13)
The tridecapeptide neurotensin (NT) acts in the mammalian brain as a primary neurotransmitter or neuromodulator of classical neurotransmitters. Morphological and functional in vitro and in vivo studies have demonstrated the existence of close interactions between NT and dopamine both in
Konstantinos Kalafatakis et al.
Regulatory peptides, 170(1-3), 7-17 (2011-05-10)
Among various hormones, which are synthesized by intestinal cells and influence enteric function, neurotensin (NT) has gained scientific attention the last three decades. This neuropeptide, mainly located in neuronal synaptic vesicles of hypothalamus and in neuroendocrine cells of the small
W Conan Mustain et al.
Current opinion in endocrinology, diabetes, and obesity, 18(1), 75-82 (2010-12-03)
Neurotensin is a 13-amino acid peptide found in the central nervous system central nervous system and the gastrointestinal tract. Since its initial discovery in 1973, neurotensin has been shown to play a role in a wide range of physiologic and
The role of neurotensin as a novel biomarker in the endoscopic screening of high-risk population for developing colorectal neoplasia
Kontovounisios C, et al.
Updates in Surgery, 69(3), 397-397 (2017)
B Mark Evers
Peptides, 27(10), 2424-2433 (2006-08-15)
Neurotensin (NT) is a brain-gut tridecapeptide that functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the periphery. NT has numerous physiologic effects on multiple organs. This review will focus on the effects
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