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Key Documents

SAB4200176

Sigma-Aldrich

Anti-JNK antibody, Mouse monoclonal

clone 1C2, purified from hybridoma cell culture

Sinonimo/i:

Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-JUN N-terminal kinase, Anti-MAP kinase 8, Anti-MAPK8, Anti-PRKM8, Anti-SAPK1, Anti-stress-activated protein kinase 1

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.44

Origine biologica

mouse

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

1C2, monoclonal

PM

antigen ~43 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1.0 mg/mL

tecniche

western blot: 1-2 μg/mL using using whole extracts of mouse NIH-3T3 cells

Isotipo

IgG2a

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MAPK8(5599)
mouse ... Mapk8(26419)
rat ... Mapk8(116554)

Descrizione generale

Anti-JNK antibody, Mouse monoclonal, (mouse IgG2a isotype) is derived from the hybridoma 1C2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant protein. JNK1 (c-Jun N-terminal kinase), also known as MAPK8 (mitogen-activated protein kinase 8) is a member of the MAP kinase family. This gene is mapped to human chromosome 10q11.

Applicazioni

Anti-JNK antibody, Mouse monoclonal has been used in immunoblotting and enzyme linked immunosorbent assay (ELISA).

Azioni biochim/fisiol

JNK1 (or MAPK8) is a serine threonine kinase that is a key regulator of cellular apoptosis. During the lack of NFkB stiμLation; persistent activation of JNK1 results in TNF-a induced cell death. However, JNK1 may also function as an apoptotic inhibitor. For instance; JNK1 interacts with WOX1 to inhibit apoptosis. Furthermore, JNK1 phosphorylates Bcl-2 to mediate starvation-induced autophagy, and also activates SIRT1 by phosphorylation during conditions of oxidative stress. JNK1 is activated by UV irradiation and oncoproteins and hence may be implicated in cancer propagation
Monoclonal Anti-JNK antibody is specific for human, mouse and rat JNK1 (43 kDa) and/or JNK2 (55 kDa).
JNK1 is also involved in UV (ultra violet) radiation induced apoptosis, which is thought to be related to cytochrome C-mediated cell death pathway.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus
Porto RR, et al.
Neuroscience, 375, 108-118 (2018)
The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss
Kim BJ, et al.
Advances in Experimental Medicine and Biology, Adv(Exp), Med-Med (2018)
JNK Signaling in Apoptosis
Dhanasekaran DN, et al.
Oncogene, 27(48), 6245-6245 (2008)
Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes
Daniele S, et al.
Journal of Neuroinflammation, 12(1), 1-24 (2015)
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-
Daniele S, et al.
Cellular Signalling, 27(8), 1609-1629 (2015)

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