SAB3500654
Anti-SIGLEC15 antibody produced in rabbit
affinity isolated antibody
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
PM
36 kDa
Reattività contro le specie
human, rat, mouse
Concentrazione
1 mg/mL
tecniche
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SIGLEC15(284266)
Categorie correlate
Descrizione generale
Sialic acid binding Ig like lectin 15 (SIGLEC15) is part of the Siglec family of glycan-recognition proteins. It is expressed in a subset of macrophages. This type-I transmembrane protein possesses two immunoglobulin-like domains, a transmembrane domain and a short cytoplasmic tail. The SIGLEC15 gene is localized on human chromosome 18q12.3.
Immunogeno
Antibody was raised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.
Azioni biochim/fisiol
Sialic acid binding Ig like lectin 15 (SIGLEC15) recognizes a tumor-linked glycan structure called the sialyl-Tn (sTn) antigen. It is expressed on tumor-associated macrophages in tumor tissues. The protein acts as a signal transducer. SIGLEC15 associates with the adaptor protein DNAX activation protein of 12kDa (DAP12) and transduces a signal to spleen tyrosine kinase (Syk).
Caratteristiche e vantaggi
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500654.
Stato fisico
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.
Glycobiology (2007)
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-? secretion from monocytes/macrophages through the DAP12-Syk pathway.
Takamiya R
Glycobiology (2013)
Jiao Hu et al.
Theranostics, 11(7), 3089-3108 (2021-02-05)
Rationale: Siglec15 is an emerging target for normalization cancer immunotherapy. However, pan-cancer anti-Siglec15 treatment is not yet validated and the potential role of Siglec15 in bladder cancer (BLCA) remains elusive. Methods: We comprehensively evaluated the expression pattern and immunological role
Kaiqin Sheng et al.
International journal of molecular sciences, 24(1) (2023-01-09)
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) has been identified as a crucial immune suppressor in human cancers, comparable to programmed cell death 1 ligand (PD-L1). However, the regulatory mechanisms underlying its transcriptional upregulation in human cancers remain largely unknown. Here
Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region
Huan Cao
Immunogenetics, 401-477 (2009)
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.