SAB3500252

Anti-TIM-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-T cell immunoglobulin and mucin domain containing protein 1
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: predicted mol wt 40 kDa
• Reattività contro le specie: human, mouse
• tecniche: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso NCBI: NP_036338
• N° accesso UniProt: Q96D42
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HAVCR1(26762)

Descrizione

Descrizione generale

Hepatitis A virus cellular receptor 1 (HAVCR1) or T-cell immunoglobulin and mucin protein (TIM-1) is a type 1 transmembrane glycoprotein. The protein is found in the apical membrane of cells. It is expressed in the kidney, testis and activated CD4⁺ T-cells. It possesses a six-cysteine immunoglobulin-like domain, a T/SP rich domain and two N-glycosylation sites. The TIM-1 gene is localized on human chromosome 5q33.2.

Immunogeno

TIM-1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human TIM-1.

Applicazioni

Anti-TIM-1 antibody produced in rabbit has been used in immunofluorescence.

Azioni biochim/fisiol

Hepatitis A virus cellular receptor 1 (HAVCR1) regulates susceptibility to human immunodeficiency virus-1 (HIV-1) infection. It is upregulated in injured kidneys. HAVCR1 inhibits the activation of the Ga12 G-protein by blocking its association to GTP. Polymorphisms in the protein have been associated with immune dysfunction.

Caratteristiche e vantaggi

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500252.

Stato fisico

Supplied in PBS with 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable