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Documenti fondamentali

SAB2501087

Sigma-Aldrich

Anti-Uncoupling Protein 2/UCP2 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-SLC25A8, Anti-UCPH, Anti-Uncoupling protein 2

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

goat

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

mouse, rat

tecniche

immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

P70406

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... UCP2(7351)

Categorie correlate

Descrizione generale

Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein. It expressed in various regions of the brain. In non-human primates, it is present in the hypothalamic nuclei, pituitary gland, brainstem, ventral tegmental area and substantia nigra. It is located on human chromosome 11q13.

Immunogeno

Peptide with sequence C-DSVKQFYTKGSEH from the internal region of the protein sequence according to NP_003346.2.

Applicazioni

Anti-uncoupling protein 2/UCP2 antibody has been used in immunoblotting.

Azioni biochim/fisiol

Uncoupling protein 2 (UCP2) controls energy metabolism and decreases the production of reactive oxygen species and guards against reperfusion damage. It plays a vital role in uncoupling electron transport from adenosine triphosphate (ATP) formation.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
7716S6P2
7716C2G2P2
7716C2G2
7716P1

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Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto (mito) phagy markers
Marques A I, et al.
Neuroscience, 301(8), 480-495 (2015)
The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke After Recanalization
Cicuendez I D M, et al.
Neuromolecular Medicine, 19(4), 571-578 (2017)
Uncoupling protein 2 region on chromosome 11q13 is not linked to markers of obesity in familial type 2 diabetes
Elbein S C, et al.
Diabetes, 46(12), 2105-2108 (1997)
Jelena Stevanović-Silva et al.
Metabolism: clinical and experimental, 116, 154704-154704 (2021-01-10)
Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle
Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
Heise, et al.
PLoS ONE, 12(8), e0181392-e0181392 (2017)

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