S9652

Safrole

≥97%

• Sinonimo/i: 4-Allyl-1,2-methylenedioxybenzene, 5-Allyl-1,3-benzodioxole
• Formula empirica (notazione di Hill): C₁₀H₁₀O₂
• Numero CAS: 94-59-7
• Peso molecolare: 162.19
• Beilstein: 136380
• Numero CE: 202-345-4
• Numero MDL: MFCD00005841
• Codice UNSPSC: 12352200
• ID PubChem: 24899851
• NACRES: NA.25

Proprietà

• Tensione di vapore: 1 mmHg ( 63.8 °C)
• Saggio: ≥97%
• Colore: yellow
• Indice di rifrazione: n20/D 1.537 (lit.)
• P. eboll.: 232-234 °C (lit.)
• Punto di fusione: 11.2 °C (lit.)
• Densità: 1.095 g/mL at 25 °C (lit.)
• applicazioni: metabolomics; vitamins, nutraceuticals, and natural products
• Stringa SMILE: C=CCc1ccc2OCOc2c1
• InChI: 1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2,4-6H,1,3,7H2; ZMQAAUBTXCXRIC-UHFFFAOYSA-N

Descrizione

Descrizione generale

Safrole is used as a counter irritant and for treating parasitic infections.

Applicazioni

Safrole has been used to investigate the role of aldehyde dehydrogenase 3A1 (ALDH3A1) in conferring cisplatin resistance to head and neck squamous cell carcinoma (HNSCC).

Azioni biochim/fisiol

Safrole is one of the vital food‐borne phytotoxins. It is present in various natural products such as spices including anise, basil, nutmeg and pepper. It exhibits cytotoxic effect in human tongue squamous carcinoma SCC‐4 cells by promoting apoptosis via mitochondria‐ and caspase‐dependent signal pathways.

Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.

Altre note

Principal constituent of sassafras oil

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H315,H341,H350
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 212.0 °F - closed cup
• Punto d’infiammabilità (°C): 100 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter