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S4776

Sigma-Aldrich

Somatotropin from human pituitary

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

Sinonimo/i:

STH

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About This Item

Numero MDL:
MFCD00081960
Codice UNSPSC:
51111800
NACRES:
NA.32

Ricombinante

expressed in E. coli

Livello qualitativo

200

Sterilità

non-sterile

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50

PM

predicted mol wt ~22 kDa

drug control

Home Office Schedule 4.2

Impurezze

endotoxin, tested

Solubilità

PBS: 0.100 mL, clear, colorless (with 0.1% BSA )

N° accesso UniProt

P01241
P10912

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... GH1(2688) , GHR(2690)

Descrizione generale

Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.

Applicazioni

Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.

Azioni biochim/fisiol

Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.

Ricostituzione

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
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PLoS ONE (2017)
Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review
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Clinical Pharmacology & Biopharmaceutics (2010)
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Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T-cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions. Along with its role in HIV-1 pathogenesis through complement opsonization of the virus, DC-SIGN
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