S4441

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

• Sinonimo/i: 1-Isothiocyanato-4-(methylsulfinyl)-butane
• Formula empirica (notazione di Hill): C₆H₁₁NOS₂
• Numero CAS: 4478-93-7
• Peso molecolare: 177.29
• Numero MDL: MFCD00198068
• Codice UNSPSC: 12352200
• ID PubChem: 24724610
• NACRES: NA.77

Proprietà

• product name: DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid
• Origine biologica: synthetic
• Saggio: ≥90% (HPLC)
• Forma fisica: liquid
• Solubilità: DMSO: soluble 40 mg/mL; H₂O: insoluble
• Compatibilità: for use with ABI 7500
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: CS(=O)CCCCN=C=S
• InChI: 1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3; SUVMJBTUFCVSAD-UHFFFAOYSA-N

Descrizione

Applicazioni

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Azioni biochim/fisiol

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.

Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)