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S4441

Sigma-Aldrich

D,L-Sulforaphane

≥90% (HPLC), liquid, phase II detoxification enzymes inducer

Sinonimo/i:

1-Isothiocyanato-4-(methylsulfinyl)-butane

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About This Item

Formula empirica (notazione di Hill):
C6H11NOS2
Numero CAS:
4478-93-7
Peso molecolare:
177.29
Numero MDL:
MFCD00198068
Codice UNSPSC:
12352200
ID PubChem:
24724610
NACRES:
NA.77

product name

DL-Sulforaphane, ≥90% (HPLC), synthetic, liquid

Origine biologica

synthetic

Saggio

≥90% (HPLC)

Forma fisica

liquid

Solubilità

DMSO: soluble 40 mg/mL
H2O: insoluble

Compatibilità

for use with ABI 7500

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CS(=O)CCCCN=C=S

InChI

1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
SUVMJBTUFCVSAD-UHFFFAOYSA-N

Applicazioni

LNCaP prostate cancer cells were treated with DL-Sulforaphane to study the effect on androgen receptor. Effects on malathion toxicity was studied in rats by treating them with DL-Sulforaphane.

Azioni biochim/fisiol

Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables. It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

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