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Key Documents

S1277

Sigma-Aldrich

Streptomicina

powder, BioXtra, suitable for mouse embryo cell culture

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About This Item

Formula condensata:
C21H39N7O12 · 1.5 H2SO4
Numero CAS:
Peso molecolare:
728.69
Beilstein:
3894995
Numero CE:
Numero MDL:
Codice UNSPSC:
12352207
ID PubChem:
NACRES:
NA.75

Nome Commerciale

BioXtra

Livello qualitativo

Forma fisica

powder

Potenza

≥720 I.U. per mg

tecniche

cell culture | embryo: suitable

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@@H](O[C@@H](C)[C@]2(O)C=O)O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]3NC(N)=N.CN[C@H]4[C@H](O)[C@@H](O)[C@H](CO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)[C@]5(O)C=O)O[C@@H]6[C@@H](O)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]6NC(N)=N

InChI

1S/2C21H39N7O12.3H2O4S/c2*1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;3*1-5(2,3)4/h2*4-18,26,29,31-36H,3H2,1-2H3,(H4,22,23,27)(H4,24,25,28);3*(H2,1,2,3,4)/t2*5-,6-,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,21+;;;/m00.../s1
QTENRWWVYAAPBI-YZTFXSNBSA-N

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Descrizione generale

Chemical structure: aminoglycoside

Applicazioni

Streptomycin is used to study mechanisms of streptomycin resistance and is often used together with penicillin and other agents to inhibit bacterial contamination in cell culture applications. It is recommended for use in molecular biology applications at 25-50μg/mL, in cell culture applications at 100 mg/L and in embryo culture at 50 mg/L.

Azioni biochim/fisiol

Modalità d′azione: La streptomicina agisce inibendo la sintesi delle proteine dei procarioti legandosi alla proteina S12 della subunità ribosomiale 30S. In questo modo impedisce la transizione da complesso imitativo a ribosoma di allungamento della catena. Ciò causa errori di codifica o inibisce l′avvio.

Modalità di resistenza: Una mutazione in rpsL, un gene per la proteina ribosomiale S12, impedisce il legame della streptomicina con il ribosoma. Inoltre, un′aminoglicoside fosfotransferasi inattiva la streptomicina.

Spettro antimicrobico: La streptomicina è attiva nei confronti dei batteri gram positivi e gram negativi.

Avvertenza

Solutions can be stored at 2-8°C for up to a month or at -20°C for more extended periods. At 37°C, solutions are stable for three days.

Nota sulla preparazione

Stock solutions should be prepared with sterile water at concentrations between 20-25 mg/ml.

Pittogrammi

Health hazardExclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificati d'analisi (COA)

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Articoli

Extraction and quantitative analysis of aminoglycosides in porcine tissue, using molecular imprinted polymer solid phase extraction followed by LC-MS/MS.

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.

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