S0198

Monoclonal Anti-Sonic Hedgehog peptide (N-terminal) antibody produced in rat

clone 171001, purified immunoglobulin, lyophilized powder

• Sinonimo/i: Anti-Dsh, Anti-Hhg1, Anti-Hx, Anti-Shh
• Codice UNSPSC: 51111800
• NACRES: NA.41

Proprietà

• Origine biologica: rat
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 171001, monoclonal
• Stato: lyophilized powder
• Reattività contro le specie: mouse, human
• tecniche: western blot: 1-2 μg/mL
• Isotipo: IgG2a
• N° accesso UniProt: Q15465
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SHH(6469) ; mouse ... Shh(20423)

Descrizione

Immunogeno

purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog N-terminal peptide (aa 25-198).

Azioni biochim/fisiol

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles such as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during the development of brain and nervous system.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)