R9156

Raltitrexed

≥98% (HPLC), solid

• Sinonimo/i: L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl), ICI-D-1694, ZD-1694
• Formula empirica (notazione di Hill): C₂₁H₂₂N₄O₆S
• Numero CAS: 112887-68-0
• Peso molecolare: 458.49
• Codice UNSPSC: 12352200
• ID PubChem: 329824044
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: off-white to light yellow
• Solubilità: H₂O: ≥10 mg/mL; DMSO: ≥40 mg/mL
• Ideatore: AstraZeneca
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2

Descrizione

Azioni biochim/fisiol

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives.

Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H360
• Consigli di prudenza: P201 - P301 + P310 + P330
• Classi di pericolo: Acute Tox. 2 Oral - Repr. 1B
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges