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Key Documents

R3250

Sigma-Aldrich

Retinil acetato

synthetic, matrix dispersion, 475,000-650,000 USP units/g

Sinonimo/i:

Retinolo acetato, Vitamina A acetato

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About This Item

Formula empirica (notazione di Hill):
C22H32O2
Numero CAS:
Peso molecolare:
328.49
Beilstein:
1915439
Numero CE:
Numero MDL:
Codice UNSPSC:
12352205
eCl@ss:
34058009
ID PubChem:
NACRES:
NA.79

Origine biologica

synthetic

Livello qualitativo

Forma fisica

matrix dispersion

Attività specifica

475,000-650,000 USP units/g

Colore

yellow

Punto di fusione

57-58 °C

Temperatura di conservazione

−20°C

Stringa SMILE

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
QGNJRVVDBSJHIZ-QHLGVNSISA-N

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Descrizione generale

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Applicazioni

Retinyl acetate has been used:
  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium avium subspecies paratuberculosis (MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Azioni biochim/fisiol

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Stato fisico

Dispersion in cornstarch-gelatin matrix. Oil dispersible

Risultati analitici

Activity based on HPLC comparison to USP standard.

Pittogrammi

Health hazard

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Aquatic Chronic 4 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type ABEK (EN14387) respirator filter


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Colecalciferolo ≥98% (HPLC)

Sigma-Aldrich

C9756

Colecalciferolo

Retinolo ≥95.0% (HPLC), ~2700 U/mg

Sigma-Aldrich

17772

Retinolo

5-α-Cholestane certified reference material, 10 mg/mL in chloroform

Supelco

47124

5-α-Cholestane

Retinol palmitate analytical standard

Supelco

46959-U

Retinol palmitate

Retinolo BioXtra, ≥97.5% (HPLC), ~3100 U/mg

Sigma-Aldrich

95144

Retinolo

Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis
Thompson HJ, et al.
Cancer Research, 41(4), 1413-1416 (1981)
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
Udeani GO, et al.
Cancer Research, 57(16), 3424-3428 (1997)
Therapeutic Use of Medicinal Plants and their Extracts:Phytochemistry and Bioactive Compounds (2018)
A survey of vitamin A and D contents of fortified fluid milk in Ontario
Faulkner H, et al.
Journal of Dairy Science, 83(6), 1210-1216 (2000)
Laure A N Villeneuve et al.
The British journal of nutrition, 95(4), 677-687 (2006-03-31)
The effect of the feeding period on larval development was investigated in European sea bass larvae by considering the expression level of some genes involved in morphogenesis. Larvae were fed a control diet except during three different periods (period A:

Articoli

All-trans retinoic acid (RA, ATRA) is a pleiotropic activation factor that regulates genes associated with normal vertebrate cellular processes such as cell differentiation, cell proliferation, apoptosis, and embryonic development.

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