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Merck
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Documenti fondamentali

PZ0315

Sigma-Aldrich

Rupintrivir

≥98% (HPLC)

Sinonimo/i:

AG-7088, AG7088, Ethyl (E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-4-oxoheptanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate, Ruprintrivir

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About This Item

Formula empirica (notazione di Hill):
C31H39FN4O7
Numero CAS:
223537-30-2
Peso molecolare:
598.66
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Attività ottica

[α]/D +30 to +40°, c = 0.5 in chloroform-d

Colore

white to beige

Solubilità

DMSO: 25 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

Fc1ccc(cc1)C[C@H](CC(=O)[C@@H](NC(=O)c3n[o]c(c3)C)C(C)C)C(=O)N[C@@H](C[C@@H]2CCNC2=O)\C=C\C(=O)OCC

InChI

1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1
CAYJBRBGZBCZKO-BHGBQCOSSA-N

Descrizione generale

Rupintrivir is an irreversible peptidomimetic inhibitor designed to target human rhinovirus (HRV). It was previously named as AG7088. It has been suggested that rupintrivir may be involved in vitro antiviral activity.

Azioni biochim/fisiol

Rupintrivir (AG7088) is an irreversible human rhinovirus (HRV) 3C protease inhibitor, also found to inhibit enterovirus and norovirus.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
016M4737V

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S L Binford et al.
Antimicrobial agents and chemotherapy, 49(2), 619-626 (2005-01-28)
The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variability in the
Jing Wang et al.
Journal of virology, 85(19), 10021-10030 (2011-08-05)
EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-resolution crystal structures of the EV71
Chunlong Ma et al.
ACS infectious diseases, 6(8), 2260-2270 (2020-07-22)
Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for
Kim S Robinson et al.
Science (New York, N.Y.), 370(6521) (2020-10-24)
Immune sensor proteins are critical to the function of the human innate immune system. The full repertoire of cognate triggers for human immune sensors is not fully understood. Here, we report that human NACHT, LRR, and PYD domains-containing protein 1
Sanne Boersma et al.
Cell, 183(7), 1930-1945 (2020-11-15)
RNA viruses are among the most prevalent pathogens and are a major burden on society. Although RNA viruses have been studied extensively, little is known about the processes that occur during the first several hours of infection because of a

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