PZ0193

Axitinib

≥98% (HPLC), powder, tyrosine kinase inhibitor

• Sinonimo/i: AG-013736, N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
• Formula empirica (notazione di Hill): C₂₂H₁₈N₄OS
• Numero CAS: 319460-85-0
• Peso molecolare: 386.47
• Numero MDL: MFCD09837898
• Codice UNSPSC: 51111800
• ID PubChem: 329823767
• NACRES: NA.77

Proprietà

• product name: Axitinib, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to tan
• Solubilità: DMSO: ≥8 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: CNC(=O)c1ccccc1Sc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2
• InChI: 1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+; RITAVMQDGBJQJZ-FMIVXFBMSA-N
• Informazioni sul gene: human ... FLT1(2321) , FLT4(2324) , KDR(3791)

Descrizione

Applicazioni

Axitinib has been used as a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (TKI) to study its effect on renal cancer cell proliferation in vitro. It has also been used to inhibit anterior mesenteric artery (AMA) angiogenesis in dechlorinated embryos maintained in conditioned water (CW).

Azioni biochim/fisiol

Axitinib (AG-013736) is an orally available, potent (picomolar) and selective tyrosine kinase inhibitor that blocks VEGF receptors 1, 2 and 3. The drug blocks VEGF-mediated endothelial cell survival, tube formation, and downstream signaling through endothelial nitric oxide synthase, Akt and extracellular signal-regulated kinase.

Caratteristiche e vantaggi

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Note legali

Sold for research purposes under agreement from Pfizer Inc.

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H400
• Consigli di prudenza: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Acute 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable