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PZ0016

Sigma-Aldrich

Dofetilide

≥98% (HPLC), powder, hERG channel blocker

Sinonimo/i:

N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide, UK-68798

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About This Item

Formula empirica (notazione di Hill):
C19H27N3O5S2
Numero CAS:
115256-11-6
Peso molecolare:
441.56
Numero MDL:
MFCD00869707
Codice UNSPSC:
12352200
ID PubChem:
329823685
NACRES:
NA.77

Nome del prodotto

Dofetilide, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to off-white

Solubilità

DMSO: >20 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc2ccc(NS(C)(=O)=O)cc2

InChI

1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
IXTMWRCNAAVVAI-UHFFFAOYSA-N

Informazioni sul gene

human ... KCNH2(3757)

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Azioni biochim/fisiol

Dofetilide is a Class III antiarrhythmic and hERG channel blocker. Dofetilide selectively blocks the rapid component of the delayed rectifier outward potassium current (IKr).

Caratteristiche e vantaggi

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Health hazardEnvironment
GHS08,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H360,H373,H411

Classi di pericolo

Aquatic Chronic 2 - Repr. 1B - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
030M4707V
030M47072
030M47071
030M4707

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Hanne Elming et al.
Expert opinion on pharmacotherapy, 4(6), 973-985 (2003-06-05)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Mortality, and especially morbidity caused by AF, are major and growing health problems in the western world. AF is strongly associated with arterial hypertension, congestive heart failure, valvular heart disease, ischaemic
S Durdagi et al.
Current medicinal chemistry, 18(17), 2601-2611 (2011-05-17)
The binding of various molecules to integral membrane proteins with optimal affinity and specificity is central to normal function of cell. While membrane proteins represent about one third of the whole cell proteome, they are a majority of common drug
Thom R G Stams et al.
European journal of pharmacology, 672(1-3), 126-134 (2011-10-18)
The novel antiarrhythmic drug K201 (4-[3-{1-(4-benzyl)piperidinyl}propionyl]-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine monohydrochloride) is currently in development for treatment of atrial fibrillation. K201 not only controls intracellular calcium release by the ryanodine receptors, but also possesses a ventricular action that might predispose to torsade de pointes
Daniel M Johnson et al.
Circulation. Arrhythmia and electrophysiology, 5(1), 201-209 (2011-11-15)
AZD1305 is an investigational antiarrhythmic agent for management of atrial fibrillation. It blocks various cardiac ion currents at different potencies and has atrial-predominant electrophysiological effects. We investigated the electrophysiological and proarrhythmic effects of AZD1305 versus dofetilide in dogs with chronic
Cardiovascular drugs. Dofetilide.
J P Mounsey et al.
Circulation, 102(21), 2665-2670 (2000-11-22)
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