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Merck
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Key Documents

PRS4401

Sigma-Aldrich

Anti-ZBP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

ZBP1 Antibody - Anti-ZBP1 antibody produced in rabbit, Zbp1 Antibody, Anti-DAI, Anti-DLM-1, Anti-Z-DNA binding protein 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

predicted mol wt 39-45 kDa

Reattività contro le specie

human, rat, mouse

tecniche

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

Q9H171

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ZBP1(81030)

Categorie correlate

Descrizione generale

Z-DNA binding protein 1 (ZBP1), also known as interferon (IFN) γ-inducible gene, is a cytoplasmic DNA sensor. It belongs to the family of Z-DNA binding proteins. ZBP1 is majorly expressed in the small intestine and lymphatic tissues. The gene is located on human chromosome 20q13.3.

Immunogeno

a 18 amino acid peptide from near the carboxy-terminus of human ZBP1.

Applicazioni

Anti-ZBP1 antibody produced in rabbit has been used for western blotting.

Azioni biochim/fisiol

Z-DNA binding protein 1 (ZBP1) plays a major role in DNA mediated innate immune responses. It enhances nuclear factor k-light-chain-enhancer of activated B cells (NFκB) activation and proinflammatory cytokine production.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4401.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Functional roles of pattern recognition receptors that recognize virus nucleic acids in human adipose-derived mesenchymal stem cells
Yu L, et al.
BioMed Research International, 2016 (2016)
ZBP1: innate sensor regulating cell death and inflammation
Kuriakose T and Kanneganti TD
Trends in Immunology, 39(2), 123-134 (2018)
Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies
Voutsadakis I
High Throughput, 7(4), 30-30 (2018)
Lili Yu et al.
BioMed research international, 2016, 9872138-9872138 (2017-01-21)
Human adipose-derived mesenchymal stem cells (hAD-MSCs) are mesenchymal stem cells with the capability to modulate immune responses. Evidence showing that hAD-MSCs could mediate innate immune responses through pattern recognition receptors (PRRs) is increasing. However, the roles of PRRs in regulating
Zhiqiang Zhang et al.
Nature immunology, 14(2), 172-178 (2012-12-12)
DDX41 is a sensor of intracellular double-stranded DNA (dsDNA) in myeloid dendritic cells (mDCs) that triggers a type I interferon response via the signaling adaptor STING. We identified the E3 ligase TRIM21 as a DDX41-interacting protein and found that knockdown

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