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Merck
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Documenti fondamentali

PRS2283

Sigma-Aldrich

Anti-RIP3 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

Anti-Receptor-Interacting serine-threonine kinase 3

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About This Item

Numero MDL:
MFCD03097232
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

PM

predicted mol wt 57 kDa

Reattività contro le specie

rat, human, mouse

tecniche

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

Q9QZL0

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Ripk3(56532)

Categorie correlate

Immunogeno

a peptide corresponding to amino acids 473-486 of murine RIP3.

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

Linkage

The action of this antibody can be blocked using blocking peptide SBP2283.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
22830004
22830704
2283-0704

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Douglas Ruhl et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(15), 2951-2964 (2019-02-09)
Ototoxic side effects of cisplatin and aminoglycosides have been extensively studied, but no therapy is available to date. Sensory hair cells, upon exposure to cisplatin or aminoglycosides, undergo apoptotic and necrotic cell death. Blocking these cell death pathways has therapeutic
Imene Jaadane et al.
Scientific reports, 10(1), 6733-6733 (2020-04-23)
Exposure Limit Values (ELV) for artificial lighting were defined in order to prevent light-induced damage to the retina. The evaluation of the lighting devices include the correction of their spectra by the B(λ) function or blue light hazard function, representing
Mi Wang et al.
Journal of anatomy, 237(1), 29-47 (2020-03-13)
Receptor-interacting protein 3 (RIP3) plays an important role in the necroptosis signaling pathway. Our previous studies have shown that the RIP3/mixed lineage kinase domain-like protein (MLKL)-mediated necroptosis occurs in retinal ganglion cell line 5 (RGC-5) following oxygen-glucose deprivation (OGD). However
Xia-Lian Wu et al.
Nature communications, 12(1), 1627-1627 (2021-03-14)
RIPK3 amyloid complex plays crucial roles during TNF-induced necroptosis and in response to immune defense in both human and mouse. Here, we have structurally characterized mouse RIPK3 homogeneous self-assembly using solid-state NMR, revealing a well-ordered N-shaped amyloid core structure featured
Johaiber Fuchslocher Chico et al.
Oncotarget, 9(16), 12941-12958 (2018-03-22)
The disintegrin metalloprotease ADAM17 has a critical role in intestinal inflammation and regeneration in mice, as illustrated by the dramatically increased susceptibility of ADAM17 hypomorphic (ADAM17ex/ex) mice to dextran sulfate sodium (DSS)-induced colitis. Similarly, necroptosis has been implicated in inflammatory
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