P9528
Polyuridylic acid potassium salt
Sinonimo/i:
Poly(U) potassium salt
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About This Item
Prodotti consigliati
Saggio
≥98% (TLC)
Livello qualitativo
Stato
lyophilized powder
Solubilità
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless
Temperatura di conservazione
−20°C
InChI
1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
DJJCXFVJDGTHFX-XVFCMESISA-N
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Applicazioni
Polyuridylic acid (Poly(U)), a homopolymer of uridine, is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7.
Nota sulla preparazione
Prepared from UDP using polynucleotide phosphorylase.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
David R Strayer et al.
PloS one, 7(3), e31334-e31334 (2012-03-21)
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown pathogenesis consisting of a variety of symptoms including severe fatigue. The objective of the study was to examine the efficacy and safety of a TLR-3 agonist, rintatolimod (Poly
Sun-Young Hwang et al.
Nucleic acids research, 40(6), 2724-2733 (2011-12-01)
RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/β production. In an attempt to identify novel tools that modulate IFNα/β production, we used SELEX technology to screen RNA aptamers that specifically target
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The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies. The species, factors and events that are responsible for the initiation and propagation of tau aggregation are not clearly established, even
Debipreeta Bhowmik et al.
PloS one, 7(5), e37939-e37939 (2012-06-06)
Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to the RNA triplex poly(U)(•)poly(A)(*)poly(U) was studied by various biophysical techniques. Berberine analogs bind to the RNA triplex non-cooperatively. The affinity of binding was remarkably high by about 5
Adrian C Barbrook et al.
Plant molecular biology, 79(4-5), 347-357 (2012-05-09)
Although transcription and transcript processing in the chloroplasts of plants have been extensively characterised, the RNA metabolism of other chloroplast lineages across the eukaryotes remains poorly understood. In this paper, we use RT-PCR to study transcription and transcript processing in
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