P6503

Pilocarpine hydrochloride

≥99% (titration), powder, muscarinic acetylcholine receptor agonist

• Sinonimo/i: (3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride
• Formula empirica (notazione di Hill): C₁₁H₁₆N₂O₂ · HCl
• Numero CAS: 54-71-7
• Peso molecolare: 244.72
• Beilstein: 4034491
• Numero CE: 200-212-5
• Numero MDL: MFCD00012722
• Codice UNSPSC: 12352200
• ID PubChem: 24277862
• NACRES: NA.77

Proprietà

• Nome del prodotto: Pilocarpine hydrochloride, ≥99% (titration), powder
• Livello qualitativo: 100
• Saggio: ≥99% (titration)
• Stato: powder
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Colore: white
• Punto di fusione: 202-205 °C (lit.)
• Solubilità: H₂O: 100 mg/mL
• applicazioni: forensics and toxicology; veterinary
• Malattie correlate: epilepsy
• Stringa SMILE: Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1; RNAICSBVACLLGM-GNAZCLTHSA-N
• Informazioni sul gene: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

Descrizione

Applicazioni

Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice. It has also been used to induce status epilepticus(SE) in rat.

Azioni biochim/fisiol

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pilocarpine is alkaloid isolated from the shrub Pilocarpus species. It comprises imidazole ring and γ- lactone rings in its structure. It has cholinergic potential and it stimulates the parasympathetic system. Pilocarpine is also effective for treating glaucoma. It stimulates ciliary muscle contraction by binding to muscarinic M3 receptors. It is effective in treating corneal dryness in Sjogren′s syndrome. It is a secretagogue, which improves salivary secretions in Xerostomia or a dry mouth condition in Sjogren′s syndrome patients and in radiotherapy patients with head and neck carcinoma.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Hygroscopic, light sensitive

Altre note

Shelf life of the powder is at least five years.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H330
• Consigli di prudenza: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classi di pericolo: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3