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P0597

Sigma-Aldrich

Pilocarpine nitrate

meets USP testing specifications

Sinonimo/i:

Pilocarpine nitrate salt

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About This Item

Formula empirica (notazione di Hill):
C11H16N2O2 · HNO3
Numero CAS:
148-72-1
Peso molecolare:
271.27
Beilstein:
4171406
Numero CE:
205-723-7
Numero MDL:
MFCD00078497
Codice UNSPSC:
41116107
ID PubChem:
24898116
NACRES:
NA.21

agenzia

USP/NF
meets USP testing specifications

Livello qualitativo

200

Forma fisica

crystals

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1
PRZXEPJJHQYOGF-GNAZCLTHSA-N

Informazioni sul gene

human ... CHRM1(1128) , CHRM3(1131)

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Azioni biochim/fisiol

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

Pittogrammi

Flame over circleSkull and crossbones
GHS03,GHS06

Avvertenze

Danger

Indicazioni di pericolo

H272,H302,H330

Classi di pericolo

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Codice della classe di stoccaggio

5.1B - Oxidizing hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
SLCJ0525
SLCC1969
SLCC1429
SLCC1435
SLBX7300

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Olav B Smeland et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)
Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status
Rashmi M Risbud et al.
PloS one, 8(1), e53464-e53464 (2013-01-12)
MicroRNAs regulate protein synthesis by binding non-translated regions of mRNAs and suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important role in the nervous system including controlling synaptic plasticity. Their expression is altered in disease states including stroke, head
Georgette L Suidan et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(9), 2112-2120 (2013-07-05)
Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of
Linda Holtman et al.
Epilepsia, 54(4), 589-595 (2013-02-13)
Brain inflammation occurs during epileptogenesis and may contribute to the development and progression of temporal lobe epilepsy. Recently, several studies have indicated that seizures may also increase specific blood plasma cytokine levels in animal models as well as in human
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
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