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P4651

Sigma-Aldrich

Promethazine hydrochloride

Sinonimo/i:

10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C17H20N2S · HCl
Numero CAS:
58-33-3
Peso molecolare:
320.88
Beilstein:
4166397
Numero CE:
200-375-2
Numero MDL:
MFCD00012652
Codice UNSPSC:
12352200
ID PubChem:
24277802
NACRES:
NA.77

Stato

powder

Livello qualitativo

200

Ideatore

Wyeth

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C

InChI

1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Informazioni sul gene

human ... HRH1(3269)

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Azioni biochim/fisiol

H1 histamine receptor antagonist; CNS depressant; anticholinergic.

Caratteristiche e vantaggi

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Altre note

Solubility: Freely soluble in water, in hot dehydrated alcohol and in Chloroform. Practically insoluble in ether, in acetone and in ethyl acetate.

Stato fisico

Appearance: White or faint yellow, odorless, Crystalline powder, slowly oxidizes and acquires a blue color, on prolonged exposure to air.

Applicazioni

N° Catalogo
Descrizione
Determinazione del prezzo

Avvertenze

Danger

Indicazioni di pericolo

H302,H317,H318,H411

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
039M4896V
048M4824V
019M4853V
047M4836V
066M4782V

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Chlorpromazine hydrochloride ≥98% (TLC)

Sigma-Aldrich

C8138

Chlorpromazine hydrochloride

Oil Orange SS analytical standard

Supelco

79285

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Chloroneb PESTANAL®, analytical standard

Supelco

36125

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Promazine hydrochloride VETRANAL®, analytical standard

Supelco

46674

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Pyrilamine maleate salt

Sigma-Aldrich

P5514

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Sulfamethazine-(phenyl-13C6) hemihydrate VETRANAL®, analytical standard

Supelco

32519

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Hydroxyzine dihydrochloride ≥97%

Sigma-Aldrich

H8885

Hydroxyzine dihydrochloride

A B Wright et al.
Ultrasound in medicine & biology, 25(2), 241-247 (1999-05-13)
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in
Z Li et al.
Neuroscience, 70(1), 145-158 (1996-01-01)
Ionic mechanisms responsible for histamine-induced prolonged depolarization in supraoptic nucleus neurons were investigated using whole-cell patch recordings in horizontally prepared brain slices from adult male rats. Bath application of histamine (1-10 microM) in control medium induced membrane depolarization in nine
Frank Fasbender et al.
Archives of toxicology, 94(2), 439-448 (2020-02-16)
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide expression
Louis C Leung et al.
Nature, 571(7764), 198-204 (2019-07-12)
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide
William C Kwan et al.
The Journal of comparative neurology, 527(3), 558-576 (2018-01-03)
The primate visual brain possesses a myriad of pathways, whereby visual information originating at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto the visual cortex. The dominant retinogeniculostriate pathway has been an area of
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Chromatograms

application for HPLC

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