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P4306

Sigma-Aldrich

Platelet-Derived Growth Factor-BB human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

PDGF-BB

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About This Item

Numero MDL:
MFCD00213023
Codice UNSPSC:
12352202
NACRES:
NA.77

Nome del prodotto

Platelet-Derived Growth Factor-BB human, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in E. coli

Saggio

≥97% (SDS-PAGE)

Stato

lyophilized powder

Potenza

1.0-3.0 ng/mL EC50

Qualità

endotoxin tested

PM

24.3 kDa

Confezionamento

pkg of 10 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

tecniche

cell culture | mammalian: suitable

Impurezze

≤1 EU/μg

N° accesso UniProt

P01127

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... PDGFB(5155)

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Descrizione generale

Platelet-Derived Growth Factor (PDGF), a cationic polypeptide, is an important serum mitogen predominantly found in cells of mesenchymal origin. PDGF is mapped to human chromosome 7p22.3 and is expressed in smooth muscle cells, endothelial cells and macrophages. PDGF exists as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.

Applicazioni

Platelet-Derived Growth Factor-BB human has been used in induction of DNA synthesis and proliferation in low-concentration serum.

Azioni biochim/fisiol

Platelet-derived growth factor (PDGF) is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF elicits multifunctional actions in a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. PDGF-BB isomer is highly expressed in tumor, mediating oncogenic pericyte recruitment and is is a key regulator of angiogenesis. PDGF-BB controls bone homeostasis, repair and regeneration. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins and modulates LDL receptor binding.

Altre note

Dimer of the B chain of human PDGF.

Stato fisico

Lyophilized from a 0.2 μm filtered solution.

Risultati analitici

The biological activity is measured by the dose-dependent stimulation of thymidine uptake in BALB/c 3T3 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLCG9790
SLCG5652
SLCG1789
SLCF8919
SLCD5157

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NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.
Johansen T, et al.
Molecular and Cellular Biology, 14.1, 646-654 (1994)
The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals
Zhang XA, et al.
Oncotarget, 7(22), 33340-33349 (2016)
The role of growth factors in wound healing
David L, et al.
The Surgical Clinics of North America, 77.3, 575-586 (1997)
Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1a/CXCR4 axis
Song N, et al.
Cancer Research, 69.15, 6057-6064 (2009)
Growth factors in the treatment of early osteoarthritis
Civinini R, et al.
Clinical Cases in Mineral and Bone Metabolism : The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 10.1, 26-26 (2013)
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Articoli

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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