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P3252

Sigma-Aldrich

6-Phenyl-2-thiouracil

≥95%

Sinonimo/i:

2-Mercapto-6-phenyl pyrimidine-4-ol, 6-Phenylthiouracil, Fenucil

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About This Item

Formula empirica (notazione di Hill):
C10H8N2OS
Numero CAS:
36822-11-4
Peso molecolare:
204.25
Numero CE:
253-227-4
Numero MDL:
MFCD00059166
Codice UNSPSC:
41106305
ID PubChem:
24897877
NACRES:
NA.51

Origine biologica

synthetic (organic)

Saggio

≥95%

Stato

powder

Solubilità

DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow

Stringa SMILE

Oc1cc(nc(S)n1)-c2ccccc2

InChI

1S/C10H8N2OS/c13-9-6-8(11-10(14)12-9)7-4-2-1-3-5-7/h1-6H,(H2,11,12,13,14)
XEKNACRTWJHOCE-UHFFFAOYSA-N

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Applicazioni

6-Phenyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, HPLC, or gas chromatography.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ3429
MKCN3682
MKCK2642
MKCK2643
MKCK2398

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Sigma-Aldrich

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2-Mercapto-1-methylimidazole ≥99%

Sigma-Aldrich

301507

2-Mercapto-1-methylimidazole

S Abuín et al.
Analytica chimica acta, 617(1-2), 184-191 (2008-05-20)
A method based on ultra-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry for the determination of six thyreostatic drugs in thyroid tissue has been optimised and validated in accordance with the Decision 2002/657/EC. Samples are extracted with methanol and the extracts cleaned-up
Dexian Kong et al.
Electrophoresis, 30(19), 3489-3495 (2009-09-04)
A simple, rapid, reproducible and sensitive method based on CE with electrochemical detector was developed for the simultaneous determination of five thyreostatics including 2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 6-phenyl-2-thiouracil (PhTU) and methimazole (TAP) in animal feeds. A home-made wall-jet
Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.
M Baba et al.
Antiviral research, 17(4), 245-264 (1992-04-01)
R Schilt et al.
Journal of chromatography, 489(1), 127-137 (1989-04-07)
Methods are described for the screening and confirmation of residues of the thyreostatics thiouracil, methylthiouracil and propylthiouracil in urine samples of cattle at levels down to 25 micrograms/l. After a selective preconcentration of the thiol-containing thyreostatics on a mercurated affinity
X Huang et al.
Journal of molecular and cellular cardiology, 32(12), 2221-2228 (2000-12-13)
Two main troponin I genes, cardiac (cTnI) and slow skeletal (ssTnI), are expressed in the mammalian heart under the control of a developmentally regulated program. ssTnI is expressed first in embryonic and fetal heart, and is then downregulated by an
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