O3636
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
powder
Sinonimo/i:
ODQ
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About This Item
Formula empirica (notazione di Hill):
C9H5N3O2
Numero CAS:
Peso molecolare:
187.15
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.32
Prodotti consigliati
Saggio
≥98% (TLC)
Livello qualitativo
Stato
powder
Colore
pale yellow
Solubilità
ethanol: 1.2 mg/mL
DMSO: 5 mg/mL
H2O: insoluble
Temperatura di conservazione
2-8°C
Stringa SMILE
O=C1ON=C2C=Nc3ccccc3N12
InChI
1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
LZMHWZHOZLVYDL-UHFFFAOYSA-N
Informazioni sul gene
human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
Applicazioni
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for affinity selection-mass spectrometry (AS-MS) compound binding assay, as a soluble guanylate cyclase (sGC) inhibitor to inhibit S-nitroso-N-acetyl-DL-penicillamine (SNAP)-induced cGMP production.
Azioni biochim/fisiol
H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.
Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.
Avvertenza
Hygroscopic
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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