M4565
Matrix Metalloproteinase-7 human
~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution
Sinonimo/i:
MMP-7, Matrilysin-1
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About This Item
Numero MDL:
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Ricombinante
expressed in E. coli
Livello qualitativo
Stato
buffered aqueous solution
Attività specifica
5,000 units/mg protein
PM
20 kDa
Concentrazione
~0.1 mg/mL
N° accesso UniProt
Malattie correlate
cancer
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... MMP7(4316)
Descrizione generale
Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.
Applicazioni
Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.
Azioni biochim/fisiol
Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.
Stato fisico
Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl
Risultati analitici
One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.
Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.
Grindel BJ, et.al.
Matrix Biology, 36, 64-76 (2014)
Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions.
Cossins JA
Acta Neuropathologica, 94(6), 590-598 (1997)
Matrilysin.
Wilson, C.L. et al.
Matrix Metalloproteinases, 149-149 (1998)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Knox JD
Cytogenetics and Cell Genetics, 72(2-3), 179-182 (1996)
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Zeng ZS
Clinical Cancer Research, 8(1), 144-148 (2002)
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