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M3808

Sigma-Aldrich

MRS 2179 ammonium salt hydrate

≥98% (HPLC)

Sinonimo/i:

2′-Deoxy-N6-methyl adenosine 3′,5′-diphosphate diammonium salt

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About This Item

Formula empirica (notazione di Hill):
C11H17N5O9P2 · xNH3 · yH2O
Numero CAS:
101204-49-3
Peso molecolare:
425.23 (anhydrous free acid basis)
Codice UNSPSC:
12352200
ID PubChem:
24278551
NACRES:
NA.77

Saggio

≥98% (HPLC)

Condizioni di stoccaggio

desiccated

Solubilità

DMSO: 1.1 mg/mL
H2O: >10 mg/mL

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

N.O.CNc1ncnc2n(cnc12)[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3

InChI

1S/C11H17N5O9P2.H3N.H2O/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19;;/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22);1H3;1H2/t6-,7+,8+;;/m0../s1
DEQIORFOBOEGKZ-ZJWYQBPBSA-N

Informazioni sul gene

human ... P2RY1(5028)

Applicazioni

MRS 2179 ammonium salt hydrate has been used as a P2Y1 receptor antagonist in porcine coronary small arteries, endothelial cells, and hippocampal astrocytes.

Azioni biochim/fisiol

MRS 2179 resists localized venous thrombosis and is useful in treating thrombotic syndromes due to its platelet aggregation inhibition functionality.
Competitive P2Y1 purinoceptor antagonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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A Baurand et al.
European journal of pharmacology, 412(3), 213-221 (2001-02-13)
The effects of a potent P2Y1 receptor antagonist, N6-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179) on adenosine-5'-diphosphate (ADP)-induced platelet aggregation in vitro, ex vivo and on the bleeding time in vivo were determined. In suspensions of washed platelets, MRS2179 inhibited ADP-induced platelet shape change, aggregation
Clara Cavelier et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(1), 131-139 (2011-10-08)
Both HDLs and their major protein constituent apolipoprotein A-I (apoA-I) are transported through aortic endothelial cells. The knock-down of the ATP-binding cassette transporters A1 (ABCA1), G1 (ABCG1), and of the scavenger receptor-BI (SR-BI) diminishes but does not completely block the
Manao Kinoshita et al.
EBioMedicine, 32, 72-83 (2018-06-12)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission
Nobuhiro Moro et al.
Experimental and therapeutic medicine, 21(6), 575-575 (2021-04-15)
The aim of the current study was to determine effects of mild traumatic brain injury (TBI), with or without blockade of purinergic ATP Y1 (P2Y1) receptors or store-operated calcium channels, on extracellular levels of ATP, glutamate, glucose and lactate. Concentrations
Egor A Turovsky et al.
Biology, 10(8) (2021-08-28)
To date, there are practically no data on the mechanisms of the selenium nanoparticles action on calcium homeostasis, intracellular signaling in cancer cells, and on the relationship of signaling pathways activated by an increase in Ca2+ in the cytosol with

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