L0401
Lectin from Lycopersicon esculentum (tomato)
FITC conjugate, buffered aqueous solution
Sinonimo/i:
Lycopersicon esculentum agglutinin, LEA
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About This Item
Codice UNSPSC:
12352202
NACRES:
NA.32
Prodotti consigliati
Coniugato
FITC conjugate
Livello qualitativo
Forma fisica
buffered aqueous solution
Grado di funzionalizzazione
2.0-6.0 mol FITC per mol lectin
Temperatura di conservazione
2-8°C
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Descrizione generale
Lectins are carbohydrate binding proteins. Lectin from Lycopersicon esculentum (LEA) binds strongly to polylactosamine oligosaccharides. It is the major component of endothelial and epithelial cell surface carbohydrate.
Applicazioni
Lectin from Lycopersicon esculentum (tomato) has been used:
- for immunofluorescence staining
- for the quantification of vascular perfusion
- for the evaluation of gel perfusion efficiency
Azioni biochim/fisiol
Lectin has anti-cancer, anti-human immunodeficiency virus (anti-HIV), anti-microbial infection and blocks mucosal atrophy. It reduces type 2 diabetes and obesity, stimulates nutrient absorption and drug targeting. It is used to stain the vascular tree in the spinal cord and brain of animals. Lectin agglutinates cells and precipitates polysaccharides and glycoproteins.
LEA is not blood group specific, but has an affinity for N-acetyl-β-D-glucosamine oligomers. The lectin is a glycoprotein containing approx. equal amounts of protein and carbohydrate and is reported to inhibit the mitogenic activity of phytohemagglutinin from Phaseolus vulgaris. This lectin binds endothelial cells and is used to visualize the microvasculature.
Confezionamento
Sold on the basis of mg active conjugate.
Stato fisico
Solution in 10 mM HEPES, 0.15 M NaCl, pH 7.5, containing 0.1 mM Ca2+, 0.08% sodium azide and 5 mg/mL β-cyclodextrin.
Risultati analitici
Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 7.3, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hour incubation at 25 °C.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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