K2015

K-252a

Ready Made Solution, from Nonomuraea longicatena, >98%

• Sinonimo/i: SF 2370
• Formula empirica (notazione di Hill): C₂₇H₂₁N₃O₅
• Numero CAS: 99533-80-9
• Peso molecolare: 467.47
• Numero CE: 200-664-3
• Numero MDL: MFCD00161522
• Codice UNSPSC: 12352200
• ID PubChem: 329817131
• NACRES: NA.77

Proprietà

• Origine biologica: Nonomuraea longicatena
• Livello qualitativo: 200
• Saggio: >98%
• Stato: solution
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1; KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Informazioni sul gene: human ... NTRK1(4914) ; rat ... Prkca(24680)

Descrizione

Azioni biochim/fisiol

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor. At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures. K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c. K-252a improves psoriasis in a SCID mouse-human skin model and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Caratteristiche e vantaggi

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Stato fisico

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 188.6 °F - closed cup
• Punto d’infiammabilità (°C): 87 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)