I9660
Anti-Integrin α2b (CD41) antibody, Mouse monoclonal
clone PM6/248, purified from hybridoma cell culture
Sinonimo/i:
Anti-CD41, Anti-CD41B, Anti-GP2B, Anti-GTA, Anti-ITGA2B integrin, alpha 2b
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About This Item
Prodotti consigliati
Origine biologica
mouse
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
PM6/248, monoclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
baboon, human
Concentrazione
~1.0 mg/mL
tecniche
flow cytometry: 1-2 μg/mL using human platelets
immunoprecipitation (IP): suitable
Isotipo
IgG1
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... ITGA2B(3674)
Descrizione generale
The gene ITGA2B (integrin subunit α 2b) encodes one of the 18 α subunits of integrins, which are transmembrane α/β heterodimers. The heterodimers, in mammals, are made up of a combination of one of 18 possible α subunits together with one of eight β subunits. The α and β subunits are type-I membrane proteins that contain a single transmembrane region linking a large extracellular domain and short noncatalytic cytoplasmic tail.
Immunogeno
human platelet membranes
Applicazioni
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Azioni biochim/fisiol
Integrins function in various cellular processes, such as tissue migration during embryogenesis, cellular adhesion, cancer metastases, and lymphocyte helper and killer cell functions. The heterodimer αIIbβ3 functions primarily in platelet aggregation, a crucial process in hemostasis and thrombosis. Integrin αIIbβ3, also referred to as glycoprotein IIbIIIa is a major adhesion receptor on platelets that is capable of binding to fibrinogen upon platelet stimulation. Defects in this gene have been associated with Glanzmann thrombasthenia, an autosomal recessive bleeding disorder.
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Catherine Huang et al.
Breast cancer research : BCR, 13(4), R84-R84 (2011-09-03)
The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of
Jaewon Han et al.
Current biology : CB, 16(18), 1796-1806 (2006-09-19)
Integrin receptors, composed of transmembrane alpha and beta subunits, are essential for the development and functioning of multicellular animals. Agonist stimulation leads cells to regulate integrin affinity ("activation"), thus controlling cell adhesion and migration, controlling extracellular-matrix assembly, and contributing to
Y-Q Ma et al.
Journal of thrombosis and haemostasis : JTH, 5(7), 1345-1352 (2007-07-20)
Integrin alpha(IIb)beta(3) plays a critical role in platelet aggregation, a central response in hemostasis and thrombosis. This function of alpha(IIb)beta(3) depends upon a transition from a resting to an activated state such that it acquires the capacity to bind soluble
Melanie A Burkhardt et al.
Scientific reports, 6, 21071-21071 (2016-02-18)
Low correlations of cell culture data with clinical outcomes pose major medical challenges with costly consequences. While the majority of biomaterials are tested using in vitro cell monocultures, the importance of synergistic interactions between different cell types on paracrine signalling
Asier Jayo et al.
Haematologica, 91(10), 1352-1359 (2006-10-05)
Glanzmann thrombasthenia is an autosomal recessive bleeding disorder characterized by a life-long hemorrhagic tendency and absent or severely reduced platelet aggregation in response to agonists, caused by quantitative or qualitative abnormalities in the platelet fibrinogen receptor, integrin alphaIIb beta3. The
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