I7379

Imipramine hydrochloride

≥99% (TLC), powder, selective serotonin reuptake inhibitor

• Sinonimo/i: 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
• Formula empirica (notazione di Hill): C₁₉H₂₄N₂ · HCl
• Numero CAS: 113-52-0
• Peso molecolare: 316.87
• Numero CE: 204-030-7
• Numero MDL: MFCD00012669
• Codice UNSPSC: 12352116
• ID PubChem: 24278097
• NACRES: NA.77

Proprietà

• Nome del prodotto: Imipramine hydrochloride, ≥99% (TLC)
• Livello qualitativo: 200
• Saggio: ≥99% (TLC)
• Stato: powder
• Colore: white
• Solubilità: H₂O: 50 mg/mL
• Ideatore: Novartis
• Stringa SMILE: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H; XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A2(6530) , SLC6A4(6532)

Descrizione

Descrizione generale

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

Applicazioni

Imipramine hydrochloride has been used:

• as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
• to investigate its interaction with insulin in aqueous solution
• to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

Azioni biochim/fisiol

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with K_is of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (K_i = 25 μM).

Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters; has little effect on the dopamine transporter.

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable