I5152
Anti-Interferon-γ Receptor 1 (IFN-γ R1) antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-CD119, Anti-IFNGR, Anti-IMD27A, Anti-IMD27B
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About This Item
Prodotti consigliati
Origine biologica
goat
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
lyophilized powder
Reattività contro le specie
human
tecniche
immunocytochemistry: 5-15 μg/mL using immersion fixed human peripheral blood mononuclear cells
neutralization: suitable
western blot: 0.1 μg/mL
Isotipo
IgG
N° accesso UniProt
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... IFNGR1(3459)
Descrizione generale
Human Interferon-γ- Receptor I (IFN-γ RI) is a 25kD, 227 amino acid residue containing protein that belongs to type II cytokine receptor family. IFN-γ RI has a crucial role in ligand-binding and signaling. Ligand IFN-γ induces tyrosine phosphorylation in IFN-γ RI which in turn leads to the formation of a docking site on the activated receptor for Stat1 that specifically activates IFN-γ induced gene transcription. Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in neutralization assay using a confluent culture of HeLa cells. Goat anti-Interferon γ Receptor I (IFN-γ RI) antibody reacts specifically with recombinant human IFN-γ RI. The product has shown no cross-reactivity for recombinant human IFN-γ RII.
Immunogeno
recombinant human IFN-γ Receptor I extracellular domain expressed in NSO cells.
Applicazioni
Anti-Interferon γ Receptor I (IFN-γ RI) antibody can be used in indirect ELISA and western blot.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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O Silvennoinen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 105(7), 497-509 (1997-07-01)
Cytokines are the principal regulators of cell proliferation and differentiation of hematopoietic cells and these responses are initiated through activation of hematopoietic cytokine receptors. Although the receptor intracellular domains lack any kinase domains, activation of cytokine receptors lead to rapid
A C Greenlund et al.
The EMBO journal, 13(7), 1591-1600 (1994-04-01)
Herein we report that interferon-gamma (IFN gamma) induces the rapid and reversible tyrosine phosphorylation of the IFN gamma receptor. Using a panel of receptor intracellular domain mutants, we show that a membrane-proximal LPKS sequence (residues 266-269) is required for ligand-induced
E A Bach et al.
Annual review of immunology, 15, 563-591 (1997-01-01)
During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFN gamma-induced cellular
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