I127

ICI 118,551 hydrochloride

≥98% (HPLC), powder, β2 inverse agonist

• Sinonimo/i: (2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride
• Formula empirica (notazione di Hill): C₁₇H₂₇NO₂ · HCl
• Numero CAS: 72795-01-8
• Peso molecolare: 313.86
• Numero MDL: MFCD00153812
• Codice UNSPSC: 12352200
• ID PubChem: 24277782
• NACRES: NA.77

Proprietà

• product name: ICI 118,551 hydrochloride, ≥98% (HPLC), powder
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white
• Solubilità: H₂O: >10 mg/mL
• Stringa SMILE: Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12
• InChI: 1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1; KBXMBGWSOLBOQM-LINSIKMZSA-N
• Informazioni sul gene: human ... ADRB2(154)

Descrizione

Applicazioni

ICI 118,551 hydrochloride has been used:

• to block β-adrenergic signaling in various experiments
• to counteract degradation by endogenous T-lymphocyte monoamine oxidases
• to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Azioni biochim/fisiol

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.

ICI 118,551 hydrochloride is a highly selective β₂-adrenoceptor antagonist.

Caratteristiche e vantaggi

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Hygroscopic

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)