H4652
HMG-1 Peptide
≥90% (SDS-PAGE), lyophilized powder, Histidine-tagged, human recombinant, expressed in E. coli
Sinonimo/i:
Amphoterin, HMGB1, High-Mobility-Group protein
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About This Item
Prodotti consigliati
product name
HMG-1 human, lyophilized powder, ≥90% (SDS-PAGE), Histidine-tagged, recombinant, expressed in E. coli
Ricombinante
expressed in E. coli
Livello qualitativo
Saggio
≥90% (SDS-PAGE)
Forma fisica
lyophilized powder
PM
25 kDa
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
COC(=O)CCCCCCCCCCCCCCO
Informazioni sul gene
human ... HMGB1(3146)
Descrizione generale
215 amino acids; comprises two homologous HMG boxes, rich in basic amino acids, and an acidic tail at the carboxy-terminus
HMG-1 (high mobility group protein) is a nuclear protein of molecular weight 30kDa. It is secreted from macrophages, monocytes and necrotic cells. It is ubiquitously expressed. The protein has basic HMG (high mobility group) box domains and an acidic carboxyl-terminus.
Applicazioni
HMG-1 (high-mobility-group protein) human has been used:
- to prepare a standard curve for measuring HMG1 using ELISA (enzyme-linked immunosorbent assay) test
- to study the apoptotic ratios of Lewis cells in presence of exogenous HMG-1
- to study the changes in Th (T helper)-17 cell expansion in the presence of HMG-1 under in vitro conditions
- for the migration assay of GM7373 cells
Azioni biochim/fisiol
HMG-1 (high mobility group protein) is a non-histone chromosomal protein, which promotes the sequence specific DNA attachment of proteins. HMG1 binds DNA in a non-sequence specific manner. It is involved in DNA replication, transcription and repair. In addition, it is up-regulated in cancers and is associated with cellular growth, vasculogenesis and apoptosis regulation. In the presence of infection or injury, HMG1 is secreted and mediates inflammation. It is associated with the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and systemic lupus erythematosus (SLE).
Stato fisico
Lyophilized powder containing HEPES buffer salts, pH 7.8, NaCl, EDTA, Triton X-100, Leupeptin and AEBSF.
Risultati analitici
Tested in DNA retardation assay
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
A Taguchi et al.
Nature, 405(6784), 354-360 (2000-06-01)
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. Engagement of
X Xu et al.
Scandinavian journal of immunology, 79(6), 386-394 (2014-03-29)
Upregulated high-mobility group box 1 (HMGB1) has been found in many diseases. Nevertheless, the function of HMGB1 on modulating the proliferation of lung cancer cells (Lewis cells) and inhibiting apoptosis is poorly understood, as well as the involved intracellular signalling.
Tian-Tian Ma et al.
PloS one, 10(4), e0123586-e0123586 (2015-04-18)
High mobility group box-1 (HMGB1), a kind of pro-inflammatory mediator, is associated with inflammatory conditions and tissue damage. Our previous study demonstrated that the circulating levels of HMGB1 correlated with disease activity of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In
H Wang et al.
Science (New York, N.Y.), 285(5425), 248-251 (1999-07-10)
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical
Julia Matena et al.
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