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H4001

Sigma-Aldrich

Hydrocortisone

≥98% (HPLC)

Sinonimo/i:

11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M

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About This Item

Formula empirica (notazione di Hill):
C21H30O5
Numero CAS:
50-23-7
Peso molecolare:
362.46
Beilstein:
1354819
Numero CE:
200-020-1
Numero MDL:
MFCD00011654
Codice UNSPSC:
51111800
ID PubChem:
24278466
NACRES:
NA.77

Origine biologica

synthetic (organic)

Livello qualitativo

300

Sterilità

non-sterile

Saggio

≥98% (HPLC)

Forma fisica

powder

Punto di fusione

211-214 °C (lit.)

Solubilità

water: 0.28 g/L at 25 °C

applicazioni

cell analysis

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
JYGXADMDTFJGBT-VWUMJDOOSA-N

Informazioni sul gene

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

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Azioni biochim/fisiol

Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360Df,H373

Classi di pericolo

Repr. 1A - STOT RE 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Hydrocortisone European Pharmacopoeia (EP) Reference Standard

H1300000

Hydrocortisone

Hydrocortisone Steroid hormone of the adrenal cortex with anti-inflammatory properties.

Sigma-Aldrich

3867

Hydrocortisone

1-(CARBAMOYLMETHYL)-PYRIDINIUM CHLORIDE AldrichCPR

S501441

1-(CARBAMOYLMETHYL)-PYRIDINIUM CHLORIDE

Hydrocortisone British Pharmacopoeia (BP) Assay Standard

BP576

Hydrocortisone

Tossina colerica ≥90% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

C8052

Tossina colerica

Hydrocortisone 21-hemisuccinate sodium salt powder, BioReagent, suitable for cell culture

Sigma-Aldrich

H2270

Hydrocortisone 21-hemisuccinate sodium salt

Margriet A B Veldhorst et al.
The Journal of clinical endocrinology and metabolism, 99(1), 285-290 (2014-01-05)
Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity. The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
Florian Hardeveld et al.
Psychoneuroendocrinology, 50, 62-71 (2014-09-03)
Although HPA-axis activity has been studied extensively in relation to depression, there is no consensus whether HPA-axis parameters predicts major depressive disorder (MDD) recurrence. We investigated whether HPA-axis parameters (cortisol awakening response (CAR), the dexamethasone suppression test (DST) and evening
K J Rademaker et al.
Archives of disease in childhood. Fetal and neonatal edition, 93(1), F58-F63 (2007-09-13)
The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in
Rachel Yehuda et al.
The American journal of psychiatry, 171(8), 872-880 (2014-05-17)
Differential effects of maternal and paternal posttraumatic stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocorticoid receptor sensitivity and vulnerability to psychiatric disorder. The authors examined the relative influences of maternal and paternal PTSD
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