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Key Documents

H0261

Sigma-Aldrich

DL-β-Hydroxybutyryl coenzyme A lithium salt

≥90%

Sinonimo/i:

DL-3- hydroxybutyryl Coenzyme A lithium salt

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About This Item

Formula empirica (notazione di Hill):
C25H42N7O18P3S
Numero CAS:
Peso molecolare:
853.62
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51

Livello qualitativo

Saggio

≥90%

Temperatura di conservazione

−20°C

Stringa SMILE

[Li].CC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23

InChI

1S/C25H42N7O18P3S.Li.H/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32;;/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41);;
HNPHARRBSFXZAL-UHFFFAOYSA-N

Applicazioni

DL-β-Hydroxybutyryl coenzyme A lithium salt has been used:

  • as a substrate in the HSD17B4 protein enzymatic assay
  • as a substrate to determine the specificity and kinetics of Hc-DHS-28 and its mutation proteins
  • as a component of the reaction buffer in S-adenosyl-L-homocysteine hydrolase (AHCY) in vitro acylation

Azioni biochim/fisiol

3-Hydroxybutyryl coenzyme A (HBCoA) is converted to bacterial polyhydroxyalkanoates (PHB) by polyhydroxybutyrate (PHB) synthases. 3-Hydroxybutyryl coenzyme A is a substrate used to measure the specificity and kinetics of β-hydroxyacyl CoA dehydrogenase.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Ping Li et al.
Biochemistry, 48(39), 9202-9211 (2009-08-29)
Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each 40 kDa). The polymerization involves covalent catalysis
Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.
Cornille E, Abou-Hamdan M, et al.
BMC Neuroscience, 23, 51-51 (2010)
An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation
Xie J, et al.
CCS Chemistry, 4(1), 304-317 (2022)
Yi Yang et al.
International journal for parasitology, 50(12), 945-957 (2020-08-29)
Haemonchus contortus could enter the diapause stage to avoid hostile conditions, however the inducing mechanism still remains poorly understood. A similar dauer strategy exists in Caenorhabditis elegans, and dauer phenomones, which are produced through a four step cycle of peroxisomal
Der-Shyan Sheu et al.
Analytical biochemistry, 393(1), 62-66 (2009-06-17)
This study presents a method to detect active polyhydroxyalkanoate (PHA) synthase on a polyacrylamide gel that combines the polyhydroxybutyrate (PHB) polymerization reaction with Sudan Black B staining. After separation of the protein samples on a modified sodium dodecyl sulfate-polyacrylamide gel

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