GW23003
Anti-CD19 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-CD19
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About This Item
Prodotti consigliati
Origine biologica
chicken
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
Reattività contro le specie
human
Produttore/marchio commerciale
Genway 15-288-23003
tecniche
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CD19(930)
Descrizione generale
CD19 is a 95kDa protein localized on the surface of nearly all B lymphocytes, and is considered to be the specific surface marker for B cells. This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of ~240 amino acids, and is involved in the regulation of B cell function. The protein is encoded by the 7.41kb cd19 gene, mapped on the short arm of human chromosome 16p11.2.
There are certain localized regions of strong net negative charge with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase), and the Lyn, Lck, and Fyn protein tyrosine kinases.
There are certain localized regions of strong net negative charge with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase), and the Lyn, Lck, and Fyn protein tyrosine kinases.
Azioni biochim/fisiol
CD19 expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen. The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.
Stato fisico
Solution in phosphate buffered saline containing 0.02% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Raccomandato
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
D T Fearon et al.
Annual review of immunology, 13, 127-149 (1995-01-01)
B lymphocytes must respond to low concentrations of antigen despite having low affinity antigen receptors during the primary immune response. CD19, a B cell-restricted membrane protein of the immunoglobulin superfamily that associates with the antigen receptor complex, may help the
Kemeng Wang et al.
Experimental hematology & oncology, 1(1), 36-36 (2012-12-06)
The human CD19 antigen is a 95 kd transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD19 is classified as a type I transmembrane protein, with a single transmembrane domain, a cytoplasmic C-terminus, and extracellular N-terminus. CD19 is a biomarker for
James N Kochenderfer et al.
Blood, 119(12), 2709-2720 (2011-12-14)
We conducted a clinical trial to assess adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor (CAR). Our clinical protocol consisted of chemotherapy followed by an infusion of anti-CD19-CAR-transduced T cells and a course of
A Pezzutto et al.
Journal of immunology (Baltimore, Md. : 1950), 138(9), 2793-2799 (1987-05-01)
The 95 Kd CD19 antigen is the broadest lineage specific surface marker for B cells: it is present on the surface of virtually all B lymphocytes, including early B progenitor cells. In this study we have evaluated the function of
L E Bradbury et al.
Journal of immunology (Baltimore, Md. : 1950), 149(9), 2841-2850 (1992-11-01)
CD19 is a member of the Ig superfamily expressed on the surface of B lymphocytes that may be involved in the regulation of B cell function. Immunoprecipitation studies with B cell lines solubilized by digitonin have shown CD19 to be
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