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G1895

Sigma-Aldrich

Gly-Pro-Arg-Pro

≥95% (HPLC)

Sinonimo/i:

GPRP, Glycyl-Prolyl-Arginyl-Proline amide

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About This Item

Formula empirica (notazione di Hill):
C18H31N7O5
Numero CAS:
67869-62-9
Peso molecolare:
425.48
Numero MDL:
MFCD00133378
Codice UNSPSC:
12352209
ID PubChem:
24894914
NACRES:
NA.32

Livello qualitativo

200

Saggio

≥95% (HPLC)

N° accesso UniProt

P02751
P04937
P11276

Temperatura di conservazione

−20°C

Stringa SMILE

NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1
WXPZDDCNKXMOMC-AVGNSLFASA-N

Informazioni sul gene

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

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Amino Acid Sequence

Gly-Pro-Arg-Pro

Descrizione generale

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.

Applicazioni

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.

Azioni biochim/fisiol

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin. Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).
Inhibits fibrin polymerization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

F4883

Fibrinogeno

Ramesh Ramapanicker et al.
Bioconjugate chemistry, 24(1), 17-25 (2012-11-16)
The synthetic tetrapeptide GPRP based on the amino-terminal GPR sequence of the fibrin α-chain binds the D-dimer protein with a dissociation constant K(D) of 25 μM. The D-dimer protein, a well-known biomarker for thrombosis, contains two cross-linked D fragments from
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The present paper shows that conformationally changed fibrinogen can expose the sites A alpha-(148-160) and gamma-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed
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Infective endocarditis (IE) caused by Staphylococcus aureus is associated with significant morbidity and mortality rates. Platelets play a dual role as adhesive cells forming associates with bacteria as well as specialized inflammatory cells. The specific role of the various factors
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PloS one, 13(9), e0203557-e0203557 (2018-09-27)
Activation of platelet-rich plasma (PRP) by pulse electric field (PEF) releases growth factors which promote wound healing (e.g., PDGF, VEGF for granulation, EGF for epithelialization). To determine after PEF activation of therapeutic PRP: 1) platelet gel strength; 2) profile of
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